A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease
Identifieur interne : 002115 ( Main/Exploration ); précédent : 002114; suivant : 002116A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease
Auteurs : Shuang Yong Ma [Finlande] ; Juha O. Rinne [Finlande] ; Yrjö Collan [Finlande] ; Matias Röytt [Finlande] ; Urpo K. Rinne [Finlande]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1996.
Abstract
We studied the pigmented neurons of the substantia nigra (SN) from 8 controls and 20 patients with Parkinson's disease (PD) using a computerized morphometric methodology. On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.
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DOI: 10.1016/0022-510X(96)00069-X
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Rinne</name><affiliation><wicri:noCountry code="no comma">Corresponding author. Tel: +358 (21) 261 1700; Fax: +358 (21) 261 1709.</wicri:noCountry></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, FIN-20520, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, University of Turku, FIN-20520, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, University of Turku, FIN-20520, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. 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On the basis of neuronal topography, several anatomic regions were outlined in the SN. In these subrogions the area, perimeter, diameter of the cell bodies and cell numbers were measured and were counted in the controls and PD patients. The measurements were made at the level of the exit of the third cranial nerve from the brain stem. In PD patients, when the whole SN was considered, the mean area, mean perimeter and diameter of the pigmented cell bodies were significantly reduced by 35%, 20% and 21% respectively from the control mean values. Regionally, the pigmented neuron area in the medial ventral part (VM), medial dorsal part (DM), lateral ventral part (VL), lateral dorsal part (DL) and pars lateralis part (PL) showed a significant reduction of 33–41% as compared to controls. In these subregions, a significant decrease in PD patients from the control mean values was seen both in the pigmented neuron perimeter, by 19–26%, and the diameter by 19–25%. This decrease in cell size suggests that, in PD patients, the remaining pigmented neurons in the SN are in a process of degeneration and atrophy. In PD patients the number of pigmented neurons in the whole SN decreased about 76% from control values. Evaluation of the influence of cell size on the apparent quantity of cells in sections indicates, however, that in PD patients the impact of true loss of pigmented neurons is far more dramatic than the impact of their decrease in size.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Ma, Shuang Yong" sort="Ma, Shuang Yong" uniqKey="Ma S" first="Shuang Yong" last="Ma">Shuang Yong Ma</name></region><name sortKey="Collan, Yrjo" sort="Collan, Yrjo" uniqKey="Collan Y" first="Yrjö" last="Collan">Yrjö Collan</name><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name><name sortKey="Roytt, Matias" sort="Roytt, Matias" uniqKey="Roytt M" first="Matias" last="Röytt">Matias Röytt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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